Unblocking security to remove the annoying Open File – Security Warning dialog on Windows Vista is harder (much harder) than it should be. Especially when you have the file sitting in a secure location such as Program Files. There are so many different solutions out there when you ask Google. Let me add one more, because
If you are getting the dialog titled "Open File – Security Warning" with the bold text: "The publisher could not be verified. Are you sure you want to run this software?", it may be a bit convulted to get rid of the problem.
First you should try going to the executable file, right click on it to bring up the properties dialog, and click the unblock button.
If this doesn't work (say if the .exe is in a secure folder such as program files), don't give up. Try moving the file to a location that isn't secure, and then unblock it.
If that doesn't work, then run screaming, and buy a mac.